parp (Cell Signaling Technology Inc)

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Cell Signaling Technology Inc parp
Parp, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 96/100, based on 1475 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/parp+rabbit+mab/Bcl-xL+Rabbit+mAb/us12595483-480-30-31
Average 96 stars, based on 1475 article reviews

parp - by Bioz Stars, 2026-10

96/100 stars

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Incubation:

Article Title: Antitumor effects of human antithymocyte globulin on peripheral T cell lymphoma via complement-dependent and -independent cytotoxicity in xenograft mouse models
Article Snippet: .. The membranes were probed overnight at 4 °C with primary antibodies of PARP Rabbit mAb (9542 T, Cell Signaling Technology, USA), Caspase 3 (D3R6Y) Rabbit mAb (14220 T, Cell Signaling Technology, US), Caspase 8 (1C12) Mouse mAb (9746 T, Cell Signaling Technology, USA), GAPDH Rabbit PolyAb (10,494–1-AP, Proteintech, China), diluted to 1:1,000 in the dilution buffer, washed with TBST three times, and then incubated with the horseradish peroxidase (HRP)-linked secondary antibodies diluted to 1: 3,000 in TBST for 1 h at 25 °C. .. The blots were imaged using a Tanon 4,600 chemiluminescent imaging system with ECL western blotting detection kit (Thermo Fisher Scientific).

Article Title: Discovery and Optimization of 4-Aminopteridin-7(8 H )-one Derivatives as Potent and Selective mTOR Inhibitors with Favorable Pharmacodynamic and Safety Characteristics.
Article Snippet: The mechanistic target of rapamycin (mTOR) is a central regulator of cell growth and a promising cancer therapeutic target.. Using structure-guided design, we developed novel 4-aminopteridin-7(8H)-one derivatives as ATP-competitive mTOR inhibitors.. The lead compound T133 (51) demonstrated exceptional mTOR inhibition (Ki = 0.17 nM) with high selectivity, effectively suppressing phosphorylation of downstream effectors, such as AKT, S6K1, and 4EBP1.

Article Title: Antitumor effects of human antithymocyte globulin on peripheral T cell lymphoma via complement-dependent and -independent cytotoxicity in xenograft mouse models.
Article Snippet: .. The membranes were probed overnight at 4 °C with primary antibodies of PARP Rabbit mAb (9542 T, Cell Signaling Technology, USA), Caspase 3 (D3R6Y) Rabbit mAb (14220 T, Cell Signaling Technology, US), Caspase 8 (1C12) Mouse mAb (9746 T, Cell Signaling Technology, USA), GAPDH Rabbit PolyAb (10,494–1-AP, Proteintech, China), diluted to 1:1,000 in the dilution buffer, washed with TBST three times, and then incubated with the horseradish peroxidase (HRP)-linked secondary antibodies diluted to 1: 3,000 in TBST for 1 h at 25 °C. .. The blots were imaged using a Tanon 4,600 chemiluminescent imaging system with ECL western blotting detection kit (Thermo Fisher Scientific).

other:

Article Title: CD47 destabilization via manipulating the SPOP-USP2 axis augments macrophage phagocytosis and cancer immunotherapy
Article Snippet: Anti-CD47 (D3O7P) rabbit mAb (63000, 1:1000), PD-L1 Rabbit antibody (13684, 1:3000), p53 Rabbit antibody (2625, 1:3000), Caspase-3 rabbit mAb (9662, 1:1000), Cleaved caspase-3 (Asp175) (5A1E) rabbit mAb (9664, 1:1000), PARP rabbit mAb (9542, 1:1000), Cleaved PARP rabbit mAb (9541, 1:1000) and GST rabbit antibody (2625, 1:3000) were purchased from Cell Signaling Technology.

Article Title: CD47 destabilization via manipulating the SPOP-USP2 axis augments macrophage phagocytosis and cancer immunotherapy.
Article Snippet: Anti- CD47 (D3O7P) rabbit mAb (63000, 1:1000), PD- L1 Rabbit antibody (13684, 1:3000), p53 Rabbit antibody (2625, 1:3000), Caspase- 3 rabbit mAb (9662, 1:1000), Cleaved caspase- 3 (Asp175) (5A1E) rabbit mAb (9664, 1:1000), PARP rabbit mAb (9542, 1:1000), Cleaved PARP rabbit mAb (9541, 1:1000) and GST rabbit antibody (2625, 1:3000) were purchased from Cell Signaling Technology.

Western Blot:

Article Title: Upregulation of endogenous TRAIL-elicited apoptosis is essential for metformin-mediated antitumor activity against TNBC and NSCLC
Article Snippet: Recombinant human TRAIL-R2/TNFRSF10B Fc chimera protein from R&D Systems (Minneapolis, MN, USA) was reconstituted at 100 μg/mL in PBS. .. Antibodies for western blot analyses were from the following sources: PARP rabbit mAb (46D11), caspase-8 mouse mAb (1C12), caspase-3 rabbit mAb (8G10), DR4 rabbit mAb (D9S1R), DR5 rabbit mAb (D4E9) (Cell Signaling Technology, Beverly, MA, USA); TRAIL mouse mAb (B35-1) (R&D Systems); and β-actin mouse mAb (clone AC-75) (Sigma Chemical, St. Louis, MO, USA). .. Antibodies for flow cytometric analyses were from Biolegend (San Diego, CA, USA): PE anti-human CD261 (DR4) Ab (307206); APC anti-human CD262 (DR5) Ab (307408); APC Mouse IgG1, κ Isotype control Ab (400120); and PE Mouse IgG1, κ Isotype control Ab (400112).

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